Marie’s research program seeks to define and control the unique and dynamic chemistry of transition metals in biology from the molecular level to the whole animal. She seeks to investigate the bioinorganic chemistry of hormones in area of research that she terms “metalloendocrinology”. Understanding the influence of metals in facilitating and disturbing this biochemical balance will impact approaches to diet, pharmacology, and toxicology as they apply to endocrine disorders spanning diabetes, liver disease, and cancer.